Project Summary

SEAP is a multi-site prospective study aiming to generate data to inform policy recommendations on enteric fever prevention and control, as well as facilitate typhoid vaccine implementation. This study will address some shortcomings of previous studies and fill knowledge gaps regarding enteric fever in Asia through collection and synthesis of existing and prospective information, especially measuring the impact of the recently introduced typhoid vaccine in routine immunization. It has been operating in Nepal for five years with approval from NHRC granted in September of 2016.
This study currently collects data by combining hospital-based inpatient and outpatient surveillance and laboratory surveillance with a healthcare utilization survey to estimate disease burden for enteric fever. SEAP also includes long-term follow-up of all blood culture confirmed cases to assess rates of relapse, mortality, and morbidity, and an economic evaluation to characterize the economic burden of enteric fever in Nepal. The surveillance component of SEAP will also form the platform for an assessment of other causes of undifferentiated fever, including but not limited to rickettsia and leptospirosis.

Study Duration

From 2016

Objectives

The objectives of this study are to characterize the burden of enteric fever in Nepal, including clinical manifestations, severity of illness, long-term sequelae of illness, antimicrobial resistance patterns of enteric fever isolates, evaluate new diagnostics and measure the vaccine impact. This study will generate data to facilitate the assessment of the impact of typhoid vaccine while also characterizing risk factors for development of severe illness among enteric fever cases.

Team Members

Principal Investigator(s): Dr. Dipesh Tamrakar, Dr. Jason Randolph Andrews

Co-Investigator(s): Prof Dr.Rajeev Shrestha, Dr Basudha Shrestha

Project Coordinator: Mr. Shiva Ram Naga, Mr. Sabin Bikram Shahi

Data Manager: Mr. Sandip Parajuli, Mr. Sanjit Kumar Makaju

Research Assistants: Ms. Aarjaya Tara Bajrachrya, Ms. Natasha Shrestha,Ms.Nisha Shrestha, Mr.Prakash Dhimal, Ms.Sarita Gosain, Mr.Subash Tamang, Ms.Mamata Maharjan

Supported by: National Institute of Health (NIH)

Collaborating Partners: Sabin Vaccine Institute(SVI) and Stanford University